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Past Events › Cambridge Neuroscience Seminars

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November 2014

Introduction to molecular neuroscience: basic techniques. DNA, RNA extraction from cells and tissues

November 4, 2014 @ 2:00 pm - 4:00 pm
John van Geest Centre for Brain Repair United Kingdom
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October 2016

Computational Neuroscience Journal Club – Rodrigo Echeveste (CBL)

October 18, 2016 @ 4:00 pm
Cambridge University Engineering Department, CBL, BE-438 (http://learning.eng.cam.ac.uk/Public/Directions)

Rodrigo Echeveste will cover: * Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences * Andres Grosmark, György Buzsáki * Science (March 2016) * "Link to paper":http://science.sciencemag.org/content/351/6280/1440 ABSTRACT: Cell assembly sequences during learning are “replayed” during hippocampal ripples and contribute to the consolidation of episodic memories. However, neuronal sequences may also reflect preexisting dynamics. We report that sequences of place-cell firing in a novel environment are formed from a combination of the contributions of a rigid, predominantly…

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June 2017

Ion Channels as Targets for CNS Disease – Prof. Derek Bowie,Department of Pharmacology and Therapeutics McGill University

June 20, 2017 @ 4:00 pm - 5:00 pm

The Bowie lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABAA receptors and more recently, Na+ channels. All ion channel families are widespread in the vertebrate brain and fulfil many important roles in healthy individuals, as well as being implicated in disease states associated with postnatal development (e.g. autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). Each ion-channel family is studied at two inter-related levels. In structural terms, ion-channel activation mechanisms are…

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January 2018

The role of DNAJB6 in protein Homeostasis – Harm H. Kampinga Department of Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands

January 25 @ 2:30 pm - 3:30 pm
The Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building, CIMR, Addenbrooke’s Site

DNAJB6 is a member of the DNAJ family, the largest family of Hsp70 co-chaperones. Over the last 7 years, we have accumulated strong evidence that DNAJB6 is an extremely efficient suppressor of amyloid formation, initiated by polyglutamine proteins involved in Huntington’s disease). In vitro and in cell models, canonical chaperones, known to act on exposed (polyQ-flanking) hydrophobic stretches, were far less or not effective under the conditions we used. DNAJB6 and -8 were effective also on other polyQ proteins (polyQ…

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