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March 2017

Electrophysiology of autocrine and paracrine NMDA receptor signalling in invasive mouse pancreatic neuroendocrine tumour cells – Dr Hugh Robinson, PDN, University of Cambridge

March 16 @ 4:00 pm - 5:00 pm
Hodgkin Huxley Seminar Room, Physiology Building, Downing Site,

N-methyl-D-aspartate receptor (NMDAR) activation is implicated in the malignant progression of many cancer types, as validated functionally through the use of NMDAR antagonists. NMDAR-mediated calcium influx and its downstream signalling depend critically on the dynamics of membrane potential and ambient glutamate concentration. Here, we have used low-noise whole-cell patch-clamp recording to investigate the electrophysiology of glutamate signalling in pancreatic neuroendocrine tumour (PanNET) cells derived from a genetically-engineered mouse model (GEMM) of PanNET, in which NMDAR signalling promotes cancer progression. Activating…

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“Axon death pathways converge on Axed to promote functional and structural axon disassembly” – Dr Lukas Neukomm, University of Massachusetts Medical School, Worcester, Massachusetts, United States

March 17 @ 1:00 pm - 2:00 pm
Brain Repair Centre, Forvie Site, Robinson Way,

Abstract not available

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Observations from the Edge of Beauty – Mr Clive Wilkins, Artist in Residence, Department of Psychology, University of Cambridge

March 17 @ 4:30 pm - 6:00 pm
Ground Floor Lecture Theatre, Department of Psychology,

Brief Abstract: In this lecture I shall argue that the ontogeny and evolution of art has been systematic, plotting the vicissitudes and changing perceptions of Homo sapiens. Patterns for mark making and the establishment of wordless thoughts, as they have unfolded over millennia, signpost aspects of our humanity, our ways of seeing and our strategies for thinking. They provide crucial insight into memory, mental time travel and perception in ways that have seldom been explored. We stand at a cross…

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Dysregulation of a novel nerve growth factor metabolic pathway causes cholinergic atrophy in Alzheimer’s disease – Dr. Claudio Cuello, McGill University, Montreal, Canada

March 20 @ 4:00 pm - 5:00 pm
MRC LMB: Max Perutz Lecture Theatre,

Abstract not available

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Sex and gender as moderators for the presentation and emergence of autism: Myths and unresolved questions – Dr Meng-Chuan Lai, Clinician Scientist in the Campbell Family Mental Health Research Institute at CAMH and O’Brien Scholar within the Child and Youth Mental Health Collaborative with CAMH, the Hospital for Sick Children and the University of Toronto.

March 21 @ 10:30 am - 11:30 am
Large Meeting Room (groundfloor), Douglas House, 18B, Trumpington Road,

Abstract not available

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"The koniocellular visual pathway" – Dr Samuel Solomon, Reader in Visual Neuroscience, Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London

March 21 @ 1:00 pm - 2:00 pm
Kenneth Craik Room, Craik-Marshall Building, Downing Site,

We generally assume that two thalamic visual pathways - the parvocellular and magnocellular - relay monocular and orientation insensitive retinal signals to visual cortex. Here I describe work with Paul Martin where we have explored the functional properties of a neglected but evolutionarily ancient thalamic pathway - the koniocellular pathway. We find that this pathway includes neurons that are binocular, neurons that are tightly tuned for contour orientation, and neurons that integrate visual with non-sensory brain signals.

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Deep Learning Book – Meeting 7 – Neural Turing Machines & Conditional Random Fields as RNNs – Group Discussion

March 21 @ 1:30 pm - 3:00 pm
CBL Room BE-438,

In this meeting we aim to cover two recent papers on Recurrent Neural Networks (which were first covered last week in Chapter 10 of the Deep Learning Book): Neural Turing Machines, Graves et al. (2014): https://arxiv.org/pdf/1410.5401.pdf Conditional Random Fields as RNNs, Zheng and Jayasumana et al. (2015): http://www.robots.ox.ac.uk/~szheng/papers/CRFasRNN.pdf Please read the material before the meeting. For future communications as well as suggesting and voting on papers/topics to cover please sign-up to our slack channel: https://cam-cbl.slack.com/signup

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Genetic connections between neurodevelopment, autism & schizophrenia – Jeffrey Barrett, Group Leader, Wellcome Trust Sanger Institute and Director, Open Targets

March 22 @ 10:30 am - 11:30 am
Large Meeting Room (groundfloor), Douglas House, 18B, Trumpington Road,

Abstract not available

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Rethinking psychosis – Dr Hisham Ziauddeen, Clinical Senior Research Associate, Department of Psychiatry and Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge

March 23 @ 12:30 pm
Seminar Room, Herchel Smith Building, Forvie Site.,

Abstract not available

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Rethinking psychosis – Dr Hisham Ziauddeen, Clinical Senior Research Associate, Department of Psychiatry and Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge

March 23 @ 12:30 pm - 1:30 pm
Seminar Room, Herchel Smith Building, Forvie Site.,

Abstract not available

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