2016-21          A randomised placebo-controlled trial of immunotherapy in patients with psychosis associated with anti-neuronal membrane antibodies (SINAPPS 2). Medical Research Council. (£2,466,231 fEC) Coles with Co-PI: Peter Jones and Belinda Lennox. MRC Reference: MR/N019067/1

2020-23          A double-blind, randomised, placebo-controlled study of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy: a phase 2b trial. Coles Multiple Sclerosis Society (£565,113)

2020-25                Centre of Excellence Grant [Coles Co-PI with Ragnhildur Thora Karadottir] Combatting progression in MS – when and how?. Multiple Sclerosis Society (£1,850,000)