Patrick Chinnery is Professor of Neurology at the University of Cambridge, head of the Department of Clinical Neurosciences and an Honorary Consultant Neurologist at Cambridge University Hospitals NHS Trust. He is a Wellcome Trust Principal Research Fellow with a lab based in the MRC Mitochondrial Biology Unit and jointly chairs the NIHR BioResource for Translational Research in Common and Rare Diseases. He was elected a Fellow of the Academy of Medical Sciences in 2009 and was appointed as MRC Clinical Director in 2019.
Patrick’s principal research interest is in understanding the role of mitochondria in human disease and developing new treatments for mitochondrial disorders. His research has involved the identification of mitochondrial and nuclear gene defects responsible for mitochondrial disorders, dissecting out the downstream disease mechanisms, and studying the molecular and cellular basis of mitochondrial DNA inheritance. Patrick leads the clinical translational research programme studying the natural history of mitochondrial diseases, with the aim of developing new treatments through investigator-led experimental medicine studies.
Professor Chinnery Laboratory
Professor Chinnery’s mitochondrial genomics and human diseases laboratory aims to determine the major nuclear and mitochondrial genetic factors that modulate the clinical expression of mitochondrial disorders. His laboratory research involves three main themes (i) defining the sub-cellular mechanism responsible for the mtDNA genetic bottleneck (ii) characterising novel nuclear gene defects in patients with Mendelian mitochondrial disorders (iii) defining the critical nuclear-mtDNA interactions responsible for mitochondrial disorders and their variable phenotype in patients.
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